Description
An increasingly aging population will add to the number of individuals suffering from amyloid. Protein Misfolding Diseases provides a systematic overview of the current and emerging therapies for these types of protein misfolding diseases, including Alzheimer's, Parkinson's, and Mad Cow. The book emphasizes therapeutics in an amyloid disease context to help students, faculty, scientific researchers, and doctors working with protein misfolding diseases bridge the gap between basic science and pharmaceutical applications to protein misfolding disease.
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Alzheimer's disease is the best-known of the growing number of disorders in which the misfolding of cell-regulating proteins--amyloids in this case--are recognized to cause cell and tissue degeneration; misfolding of other proteins is seen in type 2 diabetes and amyotrophic lateral sclerosis (ALS). In this valuable contribution to the understanding of protein- deposition diseases, Ramirez-Alvarado (biochemistry and molecular biology, Mayo Clinic College of Medicine) and international contributors to 45 chapters present an integrated approach to the process and consequences of protein aggregation. Scientists review the protein- folding process in experimental models, conditions in which this process goes awry, risk factors, and genetic variations in proteins that can influence responses to drugs. Clinicians overview current and emerging diagnostic methods and therapies. The volume includes color figures and a companion Web link. Annotation ©2010 Book News, Inc., Portland, OR (booknews.com)
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