Description
Current methods and protocols in the field of functional genomics are described in 15 chapters written by specialists in industry and universities, mostly in California (some are in Germany and the UK). Topics include clustering in life sciences, statistical methods for identifying differentially expressed genes in DNA microarrays, microarray databases, fabrication of cDNA microarrays, and preparing fluorescent probes for microarray study. Each of the clearly outlined chapters concludes with a lengthy list of references. Annotation (c) Book News, Inc., Portland, OR (booknews.com)
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This collection of robust, readily reproducible methods for microarray-based studies includes expert guidance in the optimal data analysis and informatics. On the methods side are proven techniques for monitoring subcellular RNA localization en masse, for mapping chromosomes at the resolution of a single gene, and for surveying the steady-state genome-wide distribution of DNA binding proteins in vivo. For those workers dealing with massive data sets, the book discusses the methodological aspects of data analysis and informatics in the design of microarray experiments, the choice of test statistic, and the assessment of observational significance, data reduction, and clustering.
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