Description
Ludewig (Kantonal Hospital, Switzerland) and Hoffmann (Hannover Medical School, Germany) present techniques for producing and characterizing the immunologically active cells and effector molecules used in the clinical treatment of patients. These readily reproducible protocols contain step-by-step instructions, background on principles, lists of equipment, and troubleshooting tips, and can be used for the study of dendritic cells, T-cells, monoclonal antibodies, and bone marrow transplantation. Emphasis is on preclinical and clinical applications and on the progress of clinical trials. The book will be used by immunologists, molecular biologists, and clinicians. Annotation ©2004 Book News, Inc., Portland, OR (booknews.com)
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An authoritative collection of optimal techniques for producing and characterizing the immunologically active cells and effector molecules now gaining wide use in the clinical treatment of patients. Taking advantage of the latest technologies, the authors present readily reproducible experimental protocols for the study of dendritic cells, T cells, monoclonal antibodies, and bone marrow transplantation. The emphasis is on preclinicical and clinical applications and on the progress of selected approaches in clinical trials. Additional chapters cover the molecular definition of target antigens, mathematical modeling approaches to immunotherapy, and the utilization of regulatory T cells. The protocols make it possible to study the adoptive transfer of tailored antigen-specific immune cells and to improve the clinical application of adoptive immunotherapy.
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