Description
For over 25 years the study of retroviruses has underpinned much of what is known about information transfer in cells and the genetic and biochemical mechanisms that underlie cell growth and cancer induction. Emergent diseases such as AIDS and adult T-cell lymphoma have widened even further the community of investigators directly concerned with retroviruses, a development that has highlighted the need for an integrated understanding of their biology and their unique association with host genomes. This remarkable volume satisfies that need. Written by a group of the field's most distinguished investigators, rigorously edited to provide a seamless narrative, and elegantly designed for clarity and readability, this book is an instant classic that demands attention from scientists and physicians studying retroviruses and the disorders in which they play a role.
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Offers an integrated understanding of the biology of retroviruses and their association with host genomes. Material is organized by topic rather than by virus, so that similarities and differences among retroviruses can be illuminated in the context of specific functions. Part I deals with the viral life cycle and viral structure, function, and replication, and Part II addresses the interplay between virus and host. A brief section links the two parts. Chapters can be read independently, and include introductions with references to other chapters. Appendices introduce interpretation of retroviral sequences and major problems in that specialty, summarize databases and Internet resources for virologists, list rules governing naming and classification of viruses, provide structural maps of representative retroviral genomes, and give information on accessing and viewing retroviral protein and nucleic acid structures online. Includes color illustrations, a trivia quiz, and a crossword. Annotation c. by Book News, Inc., Portland, Or.
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