Description
This reference presents cutting-edge basic and clinical research on all forms of interferon (IFN) involvement in the management of multiple sclerosis (MS)-detailing topics from IFN-receptor molecular interactions to synergy and interference with other agents such as cytotoxic drugs and chemotherapy. Features detailed research findings on IFN ß -1a (Avonex) and IFN -1b (Betaseron).
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Twenty essays investigating the role of interferons (IFN) in the treatment of multiple sclerosis (MS) expand published and unpublished work that compares all forms of IFN, treatment implications, synergy or interference with other agents, and hypotheses on how IFNs prevent disease activity in MS. The contributors report on an array of clinical experience, highlighting the molecular biology of IFN binding to its receptors, and descriptions of IFN pharmacokinetics, clinically oriented benefits and side effects of IFN in MS, the role of current and future magnetic resonance techniques for imaging MS lesions, and a review of therapy with oral and systemic IFN based on the experimental allergic encephalomyelitis (EAE) model. Includes illustrations and photographs. Annotation c. by Book News, Inc., Portland, Or.
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