This book serves two distinctive functions. It can be used as a dictionary of immunology, an alphabetical listing of immunological terms at the front of the book pin-point, by page number, an explanation in the text, or, as a convenient revision guide forstudents and an aide memoir for clinicians. There are six chapters covering all aspects of immunology, as well as explanatory diagrams and tables that summarize essential data. Well planned page layouts make it easy for the reader to cross-reference withinthe book, thereby linking various aspects of the immune system. The index of terms is placed in front of the book after the table of contents, to ease it's use as an illustrated dictionary. Terms are defined in alphabetical order within the section whereit is most logical that they should appear.Explanations of drug groups and individual drugs feature significant drug interactions and dosage and administration guidelines to provide the student with the most thorough and comprehensive information available. Key Drugs are given more thorough treatment and highlighted with an icon for quick identification in the chapter. The nursing process highlights important nursing content related to the specific drugs or drug groups. Features drug reference tables to make information more accessible and enhance the text's utility as a reference. Presents case studies highlighting specific clinical situations, with critical thinking questions, to illustrate clinical applicability. Answers are in the Instructor's Resource Kit. Presents featured boxes on nursing research, cultural implications, and home health care to highlight these important issues. Critical thinking questions for each chapter help students develop critical thinking and problem solving skills. Includes approximately 180 new illustrations to help explain how drugs work in the body and to help define other pharmacologic principles. Provides a separate disorder index that features alphabetical reference to disorders, conditions, and diseases in the text for easier access.Development of B cells in germinal centres and role of B cell receptor complexes.Internal and external pathways of antigen-processing, including the role of proteasomes in the class I pathway.Major shift of emphasis to the importance of costimulatory molecules in lymphocyte activation.Extension of CD molecules rom 78 to 130.Extension of interleukins from IL-10 to IL-17.Full integration of the sections on development of the immune response, and immune effector systems.New models for the migration of leukocytes between different tissues, including new adhesion molecules.Complete revision of mechanisms of cytotoxicity, including role of CD90.Inclusion of newly discovered complement lecitin pathway.Tolerance and autoimmunity, re-assessed in the light of the role of costimulatory molecules.Mechanisms of graft rejection linked into the basic science of antigen presentation.Cytokines required for early leukocyte development (eg Steel factor and IL-7) discussed at appropriate points.The family of chemokines and chemokine receptors outlined and placed into the context of cell migration.Special emphasis placed on the role of TH1 and TH2 cells in control of responses. Read Less