Signal transduction across biological membranes is crucial in enabling cells to recognize and respond to their environment. Over the past ten years, investigators working in prokaryotic molecular biology have identified a number of two-component genetic switches that mediate bacterial signal transduction for essential metabolic and developmental functions and numerous other cellular activities, including regulation of virulence factors in pathogenic bacteria. Edited and written by leading scientists, this book is the first comprehensive reference/text to cover hte molecular nd cellular biology of a wide variety of two-component signal transduction systems in bacteria. It will prove to be essential for microbiologists working the areas of gene expression, pathogenesis, and becterial metabolism, as well as for researchers studying antibiotic resistance and rational drug design. Read Less